1 2 Quinoline derivative MC 1626 , a putative GCN 5 histone 3 acetyltransferase ( HAT ) inhibitor , exhibits HAT - 4 independent activity against Toxoplasma gondii 5 6 7
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چکیده
independent activity against Toxoplasma gondii 5 6 7 Aaron T. Smith, Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry 8 F. Queener, and William J. Sullivan Jr.* 9 10 11 Department of Pharmacology & Toxicology, Indiana University School of Medicine, 12 Indianapolis, Indiana 13 Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartmento di Studi Farmaceutici, 14 Universita degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy 15 Istituto di Biologia e Patologia Molecolari CNR, Dip. Genetica e Biologia Molecolare, 16 Universita degli Studi di Roma “La Sapienza”, P.le A. Moro 5, I-00185 Roma, Italy 17 18 19
منابع مشابه
1 2 Quinoline derivative MC 1626 , a putative GCN 5 histone 3 acetyltransferase ( HAT ) inhibitor , exhibits HAT - 4 independent activity against Toxoplasma gondii 5 6 7 Aaron
independent activity against Toxoplasma gondii 5 6 7 Aaron T. Smith, Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry 8 F. Queener, and William J. Sullivan Jr.* 9 10 11 Department of Pharmacology & Toxicology, Indiana University School of Medicine, 12 Indianapolis, Indiana 13 Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartmento di Studi Farmaceutici, 14 Universita degli Stu...
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The yeast transcriptional adaptor GCN5 functions as a histone acetyltransferase, directly linking chromatin modification to transcriptional regulation. Homologues of yeast GCN5 have been found in Tetrahymena, Drosophila, Arabidopsis and human, suggesting that this pathway of chromatin remodelling is evolutionarily conserved. Consistent with this view, we have identified the Toxoplasma gondii ho...
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GCN5 is a histone acetyltransferase (HAT) essential for development in mammals and critical to stress responses in yeast. The protozoan parasite Toxoplasma gondii is a serious opportunistic pathogen. The study of epigenetics and gene expression in this ancient eukaryote has pharmacological relevance and may facilitate the understanding of these processes in higher eukaryotes. Here we show that ...
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